{"id":1655,"date":"2024-11-26T11:00:38","date_gmt":"2024-11-26T10:00:38","guid":{"rendered":"https:\/\/fondation-autisme.org\/?p=1655"},"modified":"2025-09-26T23:26:47","modified_gmt":"2025-09-26T21:26:47","slug":"biological-disorders-and-comorbidities","status":"publish","type":"post","link":"https:\/\/fondation-autisme.org\/en\/biological-disorders-and-comorbidities\/","title":{"rendered":"Biological disorders and comorbidities"},"content":{"rendered":"

Biochemical imbalances<\/b><\/p>\n

At the biological level, autism is characterised by a number of increasingly well-documented biochemical imbalances. These include oxidation\/reduction imbalance, oxidative stress and associated mitochondrial dysfunction, etc.<\/p>\n

Chronic inflammation<\/b><\/p>\n

Autistic individuals often display proinflammatory cytokine imbalances and may suffer from overactive or dysfunctional immune systems, with chronic neuroinflammation (neuroglial activation, presence of autoantibodies to certain brain proteins, etc.).<\/p>\n

Gastrointestinal disorders<\/b><\/p>\n

Imbalances in gut microflora are common and the likelihood of suffering from a gastrointestinal disorder is greatly enhanced relative to neurotypical control populations.<\/p>\n

Note : the above comments are largely derived from Nevison, A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors. Environmental Health 13, 73 (2014)<\/p>\n<\/div><\/div><\/div>

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For families<\/b><\/p>\n

The term comorbidities may sound off-putting, but it refers to the biological conditions that often accompany autism spectrum disorders.<\/p>\n

For you, these conditions can also serve as opportunities i.e. tools to support and enhance the well-being of your loved one with autism.<\/p>\n<\/blockquote>\n<\/div><\/div><\/div>

Recent literature reviews have converged on immune system dysregulation as a core biological feature of autism.<\/b><\/span><\/p>\n

Several sources selected in an abundant scientific literature :<\/i><\/p>\n